#3003: Sandwich Helix
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[Cueball, with his palm out, is standing in front of a class and facing Ponytail and Hairy, who are sitting at their classroom desks.]
Cueball: Always remember the #1 rule of communication:
Cueball: Sandwich Helix.
Ponytail: What does that mean?
Cueball: Unfortunately, the context has been lost.
Cueball: But we know the message, and that's the important part.
(Sourced from explainxkcd.com)
Title text:The number one rule of string manipulation is that you’ve got to specify your encodings.